Help Us Improve Life with an ICD.
You are invited to join a national research study comparing two standard, FDA-approved heart medications. Your participation could help doctors understand how to better prevent shocks and improve quality of life for everyone.
Video Resources
Who can join this study?
You can talk to your doctor about joining the study if:
You have been diagnosed with heart failure and your heart function (LVEF) is 50% or lower.
You have an ICD or CRT-D device implanted in your chest to monitor your heart rhythm.
You are currently taking metoprolol succinate (often called Toprol XL) for your heart.
Both groups receive standard, guideline-approved heart-failure therapy with close follow-up. The study compares two proven medications used in everyday care.
Metoprolol Succinate
It specifically targets the heart to keep your rhythm steady and lowers your heart rate gently.
- Slows the heart and reduces strong beating
- Focuses primarily on heart rate and contractility
- Usually causes less drop in blood pressure when standing
- Long-standing, guideline-approved heart-failure therapy
Focused Action
Carvedilol
It works on the heart and also relaxes your blood vessels, which may help lower blood pressure and reduce strain on the heart.
- Slows the heart and reduces strain
- May influence stress hormones differently
- Relaxes blood vessels
- Long-standing, guideline-approved heart-failure therapy
Broad Protection
Our Goal: Protecting Your Future
We are tracking these health markers to see which medication does a better job at keeping you safe, out of the hospital, and living your life fully.
Reducing Shocks
Fewer ICD shocks means less discomfort and anxiety
Staying Home
Keeping you healthy and out of the hospital
Living Fully
Better quality of life with your condition
Your Journey in the Study
Here's what to expect if you decide to participate.
Find a Study Site Near You
We are partnering with leading hospitals across the country.